Opiate receptor ligands

Details Opiate receptor ligands Opiate receptor ligands

1995-02-21

1996-07-16

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 25, 560 27, 560156, 560158, 562426, 562427, 562430, 562456, 562457, 562435, C07C20505, C07C27110, C07C22904

Patent

active

055368689

ABSTRACT:
Compounds of Formula 1 bind to the opioid receptors: ##STR1## wherein R.sub.1 is a group of the formula ##STR2## where W is --(CH.sub.2).sub.a -- (where a is 0, 1, or 2), --O--, --NH--, --S--, --SO--, or --SO.sub.2 --, and Ar is phenyl, phenyl-alkyl, phenyl substituted with 1-3 halo, nitro, lower alkyl, hydroxy, amino, alkylamino, dialkylamino, and/or hydroxy-lower alkyl groups, and n is 0, 1, 2, 3, or 4;

REFERENCES:
patent: 5223535 (1993-06-01), Hansen et al.
patent: 5246959 (1993-09-01), Hansen et al.
patent: 5272175 (1993-12-01), Hansen et al.
patent: 5364850 (1994-11-01), Hansen et al.

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