Opiate intermediates and methods of synthesis

Details Opiate intermediates and methods of synthesis Opiate intermediates and methods of synthesis

2005-10-21

2010-11-16

Aulakh, Charanjit S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S149000, C562S512000

Reexamination Certificate

active

07834184

ABSTRACT:
Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided. The intermediates are morphinane derivatives of formula (10), wherein X is a F or Cl and R is selected from the group consisting of an H, alkyl, aryl, acyl, formyl, COR″, CONHR″, COOR, Bn(benzyl), alkyl(methyl), and sulfonamide SO2CH2COPh.

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