Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1995-02-15
1997-03-11
Kim, Kay K. A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530408, 536 174, 546 44, 436543, 436816, 435961, 435188, C07K 1702, C07D48902, C07H 1700, A61K 39385
Patent
active
056102836
ABSTRACT:
The present invention is directed to novel opiate derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the opiates and opiate metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
REFERENCES:
patent: 3852157 (1974-12-01), Rubenstein et al.
patent: 3884898 (1975-05-01), Schneider
patent: 4231999 (1980-11-01), Carlsson et al.
patent: 4232119 (1980-11-01), Carlsson et al.
patent: 4695624 (1987-09-01), Marburg et al.
patent: 4939264 (1990-07-01), Heiman et al.
Rowley et al J. Biol. Chem. (1975) 250(10): 3759-3766.
Colbert et al (1988) J. Immunoassay 9(3 & 4): 367-383.
Blair et al (1983) J. Immunol. Methods 59:129-143.
Jung et al (1981) Biochem. Biophys. Res. Commun. 101(2): 599-604.
Cone, Edward J. et al., Forensic Drug Testing for Opiates: IV. Analytical, Sensitivity, Specificity and Accuracy of Commercial Urine Opiate Immunoassays, J. Anal. Tox. 16:72-78 (1992).
Cone, Edward J. et al., Forensic Drug Testing for Opiates:I. Detection of 6-Acetylmorphine in Urine as an Indicator of Recent Heroin Exposure; Drug and Assay Considerations and Detection Times, J. Anal. Tox. 15:1-7 (1991).
Kaiser, Carl et al., Sigma Receptor Ligands: Function and Activity, Neurotransmissions: 7: No. 1 1-8 (1991).
McKnight, Alexander and Rees, David C. Neurotransmissions: 7: No. 2 1-8 (1991).
Ram, Vishnu J. and Neumeyer, John L., Aporphines, 42. Synthesis of (R)-(-D-11-Hydroxaporphines from Morphine, J. Org. Chem. 47:4372-74 (1982).
Krafft, Grant A., et al., Photoactivable Flurophones 3. Synthesis and Photoactivation of Flurogenic Difunctionalized Fluroescerns, J. Am. Chem. Soc. 110:301-03 (1989).
Rice, Kenner, C. and May Everette L., Procedural Refinements in the N-Demethylation of Morphine and Codeine Using Phenyl Chloroformate and Hydrazine, J. Heterocyclic Chem. 14:665-66 (1977).
Rice, Kenner, C. and Jacobson, Arthur E., Preparation and Analgesic Activity of 3,6-Diacetyl-normorphine and 6-Acetylnormorphine, J. Med. Chem. 18:1033-35 (1975).
Weijlard, John and Erickson, A. E., N-Allylnormorphine JACS 64:869-70 (1942).
Brine, George A. et al., the N-Demethylation of Morphone and Codeine Using Methyl Chloroformate, Organic Preparations and Procedures, Int. 8:103-106 (1975).
Kosterlitz, H. W. et al., the assay of the agonist activities of N-methyl and N-nor-homologies of morphine derivatives by the guinea pig ileum method, J. Pharm. Pharmac. 28:325 (1976).
Rice, Kenner C., An improved Procedure for the N-Demethylation of 6,7-Benzo morphines, Morphine, and Codeine, J. Org. Chem. 40:1850-51 (1975).
Speyer, Edmund and Walther L. Uberdie Einwirkung von Sulpetriger Saure auf Morphium und Seine Derivate, Ber. 63:852-855 (1930).
J. V. Braun, Untersuchungen uber Morphium Alka, Ber. 47:2312-2331 (1914).
Biosite Diagnostics Incorporated
Kim Kay K. A.
LandOfFree
Opiate derivatives and protein and polypeptide opiate derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Opiate derivatives and protein and polypeptide opiate derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Opiate derivatives and protein and polypeptide opiate derivative will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-444601