Opiate analgesic formulation with improved safety

Details Opiate analgesic formulation with improved safety Opiate analgesic formulation with improved safety

1994-12-27

1998-11-10

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514811, 514812, 514823, A61K 3114

Patent

active

058344772

ABSTRACT:
An opiate analgesic drug formulation which induces minimal respiratory dession is provided which contains a homogeneous mixture of an opiate agonist drug component and an opiate antagonist drug component in an aqueous medium, the opiate agonist component and the opiate antagonist component being present in the mixture in a molar ratio, wherein when the drug formulation is administered to a patient in an amount sufficient for the opiate agonist drug component to induce analgesia in the patient, substantially no respiratory depression is induced in the patient.

REFERENCES:
patent: 5512578 (1996-04-01), Crain et al.
Chemical Abstracts AN 1990: 191789, Moore et al, 1990.
Chemical Abstracts AN 1977: 165459, Drummond et al, 1977.

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