Surgery – Respiratory method or device – Ozone or ion generation
Patent
1980-10-20
1982-05-11
Michell, Robert W.
Surgery
Respiratory method or device
Ozone or ion generation
424180, A61B 1700, A61K 3170
Patent
active
043288030
ABSTRACT:
This disclosure is directed to improved opthalmological surgical procedures on the human eyeball characterized by initially utilizing ultra-pure hyaluronic acid in the form of a solution containing the sodium salt thereof, in a sufficient concentration thereof to protect delicate eye tissue and cells, e.g., 0.5 to 1.0 wt. % and higher, and thereafter, significantly diluting the concentration thereof in the aqueous media (natural and/or synthetic) within the anterior segment of the eye viz, in situ, so as to arrive at a concentration of said sodium salt of hyaluronic acid of less than 0.5 wt. % and more usually from about 0.1 to about 0.3 wt. % prior to closure. Hence a significant dilution from the initial higher concentrations by a factor of at least about 2:1 and more usually from about 3:1 to about 10:1 is effected. Hence the concentration of said sodium hyaluronate in the natural and/or synthetic aqueous media left within the eyeball at the surgical site after closure of the procedure ranges from about 0.1 to about 0.3 wt. % in the anterior chamber.
REFERENCES:
patent: 4141973 (1979-02-01), Balazs
Healon, Product Information, Pharmacia.
Pape, L. G., The Use of Sodium Hyaluronate, Ophthalmology, vol. 87, 1980.
Binkhorst, C. D., American Intra-Ocular Implant Society, Journal, vol. 6 (4), Oct. 1980, pp. 340-341.
Burke Joseph Patrick
Michell Robert W.
Opthalmic Systems, Inc.
Swisher Nancy A. B.
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