Ophthalmic treatment by topical administration of cyclosporin

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only

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514 11, 514885, 514912, A61K 3700, A61K 3174

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active

046490477

ABSTRACT:
The present invention relates to a method for the treatment of either phacoanaphylactic endophthalmitis or uveitis by administering at least one cyclosporin topically to the eyes. Topical application of cyclosporin provides cyclosporin to the anterior chamber, the posterior chamber and the vitreous body of the eye.

REFERENCES:
Chem. Abst. 102:214587v (1985)--Mosteller et al.
Chem. Abst. 102:125267y (1985)--Williams et al.
Chem. Abst. 102:89788h (1985)--Boisjolv et al.
Chem. Abst. 101:103683h (1984)--Chan et al.
Chem. Abst. 101:16979v (1984)--Mannis et al.
Chem. Abst. 97 84951z (1982)--Nussenblatt et al.
Chem. Abst. 97 439c (1982)--Kana et al.
Chem. Abst. 94 185,629u (1981)--Nussenblatt et al.
Amer. J. Ophthal. 96(3) 275-282 (1983)--Nussenblatt et al.
Biosjoly et al., Prophylactic Topical Cyclosporine in Experimental Herpetic Stromal Keratitis, Arch Ophthalmol, 102, 1804, Dec. 1984.
Mosteller et al., Penetration of Topical Cyclosporine into the Rabbit Cornea, Aqueous Humor, and Serum, Arch. Ophthalmol, 103, 101, Jan. 1985.
Nussenblatt et al., Cyclosporin A Therapy in the Treatment of Intraocular Inflammatory Disease Resistant to Systemic Corticosteroids and Cytotoxic Agents, American Journal of Ophthalmology, 96, 275, Sep. 1983.
Kaswan et al., Intraocular Penetration of Cyclosporin in Rabbits, ARVO Abstracts, Investigation Ophthalmol. Supp. 25, 3, p. 38, 1984.

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