Ophthalmic solution for treatment of dry eye syndrome

Details Ophthalmic solution for treatment of dry eye syndrome Ophthalmic solution for treatment of dry eye syndrome

1986-04-28

1988-05-17

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

514915, A61K 3174

Patent

active

047449802

ABSTRACT:
A synergistic combination in an aqueous solution of a partially hydrolyzed poly(vinyl acetate) and a fully hydrolyzed poly(vinyl acetate), i.e. poly(vinyl alcohol), exhibiting a low surface tension at the water-air interface, while forming a completely wettable absorbed layer over hydrophobic solids. The combination is used as part of an ophthalmic solution including a hydrophilic low viscosity polymer, poly(N-glucose) or poly(N-vinyl pyrrolidone) with higher than normal oncotic pressure in a physiologically compatible electrolytic solution base. The formulation is effective in treating the two major underlying causes of the dry eye syndrome; ocular surface disorder and tear film abnormalities resulting in tear film instability. It can also be effective as an aqueous vehicle for topically used ophthalmic drugs or nutrients.

REFERENCES:
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patent: 3968201 (1976-07-01), Ryde et al.
patent: 3991759 (1976-11-01), Urguhart
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patent: 4529535 (1985-07-01), Sherman
patent: 4560491 (1985-12-01), Sherman
Lemp-"Tear Substitutes In The Treatment of Dry Eyes"-Int. Ophthal. Clin. 13, 145-153, (1973).

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