Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1988-05-16
1989-11-28
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Lymphokine
424 78, 514915, A61K 3174, A61K 3179
Patent
active
048836583
ABSTRACT:
A synergistic combination of an aqueous solution of a partially hydrolyzed poly(vinyl acetate) and a fully hydrolyzed poly(vinyl acetate), i.e. poly(vinyl alcohol), exhibiting a low surface tension at the water-air interface, while forming a completely wettable absorbed layer over hydrophobic solids. The combination is used as part of an ophthalmic solution including a hydrophilic low viscosity polymer, poly(N-glucose) or poly(N-vinyl pyrrolidone) with higher than normal oncotic pressure in a physiologically compatible electrolytic solution base. The formulation is effective in treating the two major underlying causes of the dry eye syndrome; ocular surface disorder and tear film abnormalities resulting in tear film instability. It can also be effective as an aqueous vehicle for topically used ophthalmic drugs or nutrients.
REFERENCES:
patent: 3767789 (1973-10-01), Rankin
patent: 3856919 (1974-12-01), Rankin
patent: 3868445 (1975-02-01), Ryde et al.
patent: 3907985 (1975-09-01), Rankin
patent: 3920810 (1975-12-01), Rankin
patent: 3947573 (1976-03-01), Rankin
patent: 3968201 (1976-07-01), Ryde et al.
patent: 3987163 (1976-10-01), Rankin
patent: 3991759 (1976-11-01), Urquhart
patent: 4039662 (1977-08-01), Hecht et al.
patent: 4120949 (1978-10-01), Bapatta et al.
patent: 4131651 (1978-12-01), Shah et al.
patent: 4271144 (1981-06-01), Holly
patent: 4343787 (1982-08-01), Katz
patent: 4409205 (1983-10-01), Shively
patent: 4529535 (1985-07-01), Sherman
patent: 4560491 (1985-12-01), Sherman
patent: 4744980 (1988-05-01), Holly
Lemp-"Tear Substitute in the Treatment of Dry Eyes"--Int. Ophthal. Clin. 13, 145-153 (1973).
International Search Report PCT/US80?00696.
Holly, "Clinical Pharmacology of the Anterior Segment", Int. Ophtal. Clin., No. 3, vol. 20, 171-185 (1980).
Holly, "Surface Chemical Evaluation of Artificial Tears and Their Ingredients. III Dynamic Properties", Contact and Intraocular Lens Medical Journal, vol. 5, No. 1, pp. 21-33, Jan., Mar. 1979.
Holly "Surface Chemical Evaluation of Artificial Tears and Their Ingredients. II Interaction with a Superficial Lipid Layer", Contact and Intraocular Lens Medical Journal, vol. 4, No. 3, pp. 52-65, Jul.-Sep. 1978.
Holly, "Surface Chemical Evaluation of Artificial Tears and their Ingredients. I Interfacial Activity at Equilibrium", Contact & Intraocular Lens Medical Journal, vol. 4, No. 2, pp. 14-31, Apr.-Jun. 1978.
Holly-"Physical Chemistry of the Normal and Disordered Tear Film", Trans. Optham. Soc. U.K., 104, pp. 374-380 (1985).
Holly, "Biophysical Aspects of Epithelial Adhesions to Stroma", Investigative Ophtalmology & Visual Science, vol. 17, No. 6, pp. 552-557, 1978.
Lipovsky Joseph A.
Robinson Douglas W.
LandOfFree
Ophthalmic solution for treatment of dry-eye syndrome does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ophthalmic solution for treatment of dry-eye syndrome, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ophthalmic solution for treatment of dry-eye syndrome will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-580914