Ophthalmic solution for intraocular pressure reduction

Details Ophthalmic solution for intraocular pressure reduction Ophthalmic solution for intraocular pressure reduction

1980-09-03

1983-05-10

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

A61K 3134

Patent

active

043829538

ABSTRACT:
An ophthalmic solution suitable for adjusting intraocular pressure comprising (A) an ophthalmologically acceptable, water-soluble salt of 2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran, (B) benzalkonium chloride or benzethonium chloride, and (C) a member selected from polyvinyl alcohol, methyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose and hydroxypropylmethyl cellulose, the solution being adjusted to pH 5.0 to 8.0 with a buffer agent. The components (B) and (C) increase greately the intraocular penetration of the component (A) and reduce the irritation to eye of the component (A) so that the pharmacological action of the component (A) can be effectively exhibited. The ophthalmic solution produces an excellent effect on decreasing of intraocular pressure with reduced irritation to eye and stability for a long term.

REFERENCES:
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patent: 4189496 (1980-02-01), Cragoe et al.
patent: 4229467 (1980-10-01), Parker
patent: 4237130 (1980-12-01), Cragoe et al.
Brit J. Ophthal., (1973) pp. 301-303-Bonomi et al.
Chem. Abst. 77, 775(w) (1972)-Pecori-Giraldi.
Chem. Abst. 81, 131,068(y) (1974)-Stankiewicz et al.
Chem. Abst. 82, 38754(e) (1975)-Sharaf et al.

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