Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Carbohydrate or lignin – or derivative
Patent
1995-07-21
1998-06-23
Schoffer, Joseph L.
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Carbohydrate or lignin, or derivative
424 7804, 424427, 514 53, 514777, 514915, A61K 3174, A01N 5926
Patent
active
057706280
ABSTRACT:
Ophthalmic preparation for use as artificial tear containing hyaluronate as a viscosity thickener, preferably in the form of sodic salt and having a molecular weight of 500,000 to 4,000,000 daltons, at a concentration of 0.05 to 2% by weight, as well as the following minimum quantities of ionic species: 40 mmol/l sodium ion, 12 mmol/l potassium ion, 0.4 mmol/l calcium ion, 0.4 mmol/l magnesium ion, 50 mmol/l chloride ion, 7 mmol/l phosphate ion and, preferably, 0.7 mmol/l citrate ion. The formulation, which as an osmolarity of 140 to 280 mOsm/l, is useful for the treatment of keratoconjunctivitis sicca and may be administered whenever the use of artifical tears is advisable, e.g. for the treatment of eye irritations caused by environmental conditions or contact lenses.
REFERENCES:
patent: 4409205 (1983-10-01), Shively
patent: 5106615 (1992-04-01), Dikstein
patent: 5166331 (1992-11-01), Della Valle et al.
patent: 5409904 (1995-04-01), Hecht et al.
Bachman et al., Essential Ions for Maintenance of the Corneal Epithelial Surface:, Invest. Opthalmal. Vis. Sci., 26, 1484-88 (1985).
Risomondo et al., "Electrolyte Composition of Lacrimal Gland Fluid and Tears of Normal and Vitamin A--Deficient Rabbits" CLAO J 15(3), 222-229 (1989).
Green et al., "Tear Potassium Contribute to Maintenance of Corneal Thickness", Opthalmic Res. 24, 99-102 (1992).
Iwata, The Preocular Tear Film and the Dry Eye Syndrome, Intl. Ophthalmology Clinis, Holly and Lemp, eds., Little Brown, 31-32, (1973).
Rolando et al., "The Effect of Hyphosmolarity on Tear Mueus Ferning", Fortschr Opthalmol, 83, 644-646 (1986).
Nelson, "Impression Cytology", Cornea 7(1), 71-81 (1988).
Laboratoire Medidom S.A.
Schoffer Joseph L.
Shelborne Kathryne E.
LandOfFree
Ophthalmic preparation for use as artificial tear does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ophthalmic preparation for use as artificial tear, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ophthalmic preparation for use as artificial tear will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1395180