Ophthalmic liposomes

Details Ophthalmic liposomes Ophthalmic liposomes

1986-07-28

1989-02-14

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 43, 264 46, 424 11, 424427, 4284022, 436829, 514912, 514914, 514966, A61K 3722, A61K 966, B01J 1302

Patent

active

048045390

ABSTRACT:
A liposome composition with enhanced retention on ocular surfaces, for use in ophthalmic drug delivery and dry eye treatment. The liposomes contain about 10-40 mole percent of an amine-derivatized lipid component in which a charged amine group is spaced from a lipid polar head region by a carbon-containing spacer arm at least 3 atoms in length. The liposomes preferably have a close packed lipid structure produced by inclusion of between 20-50 mole percent of cholesterol or an amine-derivatized cholesterol, and/or phospholipids with predominantly saturated acyl chain moieties. The liposomes may be suspended in an aqueous medium containing a high-viscosity polymer, formulated in paste form, or embedded in a polymer matrix, to enhance further the retention of liposomes on a corneal surface.

REFERENCES:
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4350676 (1982-09-01), Laties et al.
patent: 4480041 (1984-10-01), Myles et al.
patent: 4515736 (1985-05-01), Deamer
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4565696 (1986-01-01), Heath et al.
patent: 4619913 (1986-10-01), Luck et al.
Gregoriadis: "The Carrier Potential of Liposomes in Biology and Medicine", New England Journal of Medicine, vol. 295, No. 13, Sep. 23, 1976, pp. 704-710.
M. S. Wu, J. C. Robbins, R. L. Bugianesi et al., titled: Modified in vivo Behavior of Liposomes Containing Synthetic Glycolipids, Bio. Biophysica Acta, 674 (1981) 19-29, Elsevier North-Holland Biomedical Press.
Toshiyuki Nagata, Hansjorg Eibl and Georg Melchers, Fusion of Plant Protoplasts Induced by a Positively Charged Synthetic Phospholipid, pp. 460-462, 0341-0382/79/0500-0460 $01.00/0.
M. M. Ponpipom, T. Y. Shen, J. D. Baldeschwieler, and Po-Shun Wu, titled: Modification of Liposome Surface Properties by Synthetic Glycolipids, (Chapter 7), vol. III, pp. 95-115, Liposome Technology.
M. R. Mauk, R. C. Gamble and J. D. Baldeschwieler, titled: Targeting of Lipid Vesicles: Specificity of Carbohydrate Receptor Analogues for Leukocytes in Mice, Prc.: Natl. Acad. Sci. U.S.A., vol. 77, No. 8, pp. 4430-4434, Aug. 1980, Biochemistry.
H. E. Schaeffer and D. L. Krohn, titled: Liposomes in Topical Drug Delivery, pp. 220-227, Invest. Ophthalmol. Vis. Sci., Feb. 1982, 0146-0404/82/020220.

Affiliated with

Also associated with

Rating

Ophthalmic liposomes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ophthalmic liposomes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ophthalmic liposomes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1364627