Ophthalmic fluid

Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Carboxylic acid ester

Reexamination Certificate

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C514S912000, C514S915000

Reexamination Certificate

active

07115667

ABSTRACT:
An ophthalmic fluid containing at least one triglyceride, diglyceride, or monoglyceride which is chemically similar or compatible with compounds found naturally in the lipid layer of the tear film of an ocular substrate. Preferably the glycerides are derived from a fatty acid containing at least one unsaturated bond in a cis-configuration in the fatty acid residue. The ophthalmic fluid is arranged in use to provide a protective film across a tear film of an ocular substrate. Furthermore, the ophthalmic fluid is also arranged in use to provide a protective film intermediate a lipid layer of the tear film of the ocular substrate and a contact lens.

REFERENCES:
patent: 4259202 (1981-03-01), Tanaka et al.
patent: 5981607 (1999-11-01), Ding et al.
patent: PCT/US93/00044 (1993-01-01), None
patent: PCT/US95/06302 (1995-05-01), None
patent: PCT/EP96/00697 (1996-02-01), None
patent: WO 98 16217 (1998-04-01), None
Harvey, et al., “Identification by Combined Gas Chromatography—Mass Spectrometry of Constituent Long—Chain Fatty Acids and Alcohols from the Meibomian Glands of the Rat and a Comparison with Human Meibomian Lipids”,Journal of Chromatography, pp. 253-263 (1987).
Medline Abstract No. 952309493; J Phar Pharmacol Dec. 1994;46(12):p. 986-93.
Medline Abstract No. 91172507; 1: Ophthalmologica 1990:201(4):206-12.

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