Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-08-27
2009-08-18
Solola, Taofiq A (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S469000, C549S058000, C549S467000
Reexamination Certificate
active
07576122
ABSTRACT:
This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
REFERENCES:
patent: 4690931 (1987-09-01), Wick et al.
patent: 5151444 (1992-09-01), Ueno et al.
patent: 5296504 (1994-03-01), Stjernschantz et al.
patent: 5352708 (1994-10-01), Woodward et al.
patent: 5422368 (1995-06-01), Stjernschantz et al.
patent: 5573758 (1996-11-01), Adorante et al.
patent: 5889052 (1999-03-01), Klimko et al.
patent: 5925342 (1999-07-01), Adorante et al.
patent: 1114816 (2001-07-01), None
patent: 1286861 (1969-09-01), None
patent: WO 89/10757 (1989-11-01), None
patent: WO 94/13275 (1994-06-01), None
patent: WO 94/28900 (1994-12-01), None
patent: WO 96/33719 (1996-10-01), None
patent: WO 01/46140 (2001-06-01), None
patent: WO 01/70702 (2001-09-01), None
patent: WO 02/24647 (2002-03-01), None
patent: WO 02/42268 (2002-05-01), None
patent: WO 2004/043354 (2004-05-01), None
patent: WO 2004/085431 (2004-10-01), None
A. M. Harman et al., “Development and Aging of Cell Topography in the Human Retinal Pigment Epithelium”, 1997, pp. 2016-2026, vol. 38, No. 10, Investigative Ophthalmology & Visual Science.
E. L. Eliel et al., “Chirality in Molecules Devoid of Chiral Centers”, 1994, pp. 1119-1190, Chap. 14,Stereochemistry of Organic Compounds.
S. M. Berge et al., “Pharmaceutical Salts”, 1977, pp. 1-19, vol. 66, No. 1, J. of Pharmaceutical Sciences.
M. Topolski, “Electrophilic Reactions of Carbenoids. Synthesis of Fused Heterocyclic Systems via Intramolecular Nucleophilic Substitution of Carbenoids”, 1995, pp. 5588-5594, vol. 60, J. Org. Chem.
C.F. H. Allen et al., “Thiosalicylic Acid”, 1991-2002, pp. 580, Coll. vol. 2, Organic Syntheses.
M. Hanner et al., “The Beta Subunit of the High Conductance Calcium-Activated Potassium Channel”, 1998, pp. 16283-169296, vol. 273, No. 26, J. of Biological Chemistry.
A. F. Abdel-Magid et al., “Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures”, 1996, pp. 3849-3862, vol. 61, J. Org. Chem.
P. M. Vasallo et al., “Expression of Na,K ATPase Alpha Subunit Isoforms in the Human Ciliary Body and Cultured Ciliary Epithelial Cells”, 1989, pp. 243-252, vol. 141, J. of Cellular Physiology.
E. Tsuji et al., “Preparation of 3-Acetoacetylaminobenzo[b] Furan Derivatives with Cysteinyl Leukotriene Recptor 2 Antagonistic Activity”, 2003, pp. 3139-3141, vol. 1, Org. Biomol. Chem.
G. Dyker et al., “Palladium-Catalyzed C-H Activation oat Methoxy Groups for Cross-Coupling Reactions: A New Approach to Substituted Benzo {b} Furans”, 1993, Vol. 58, p. 6426-6428, American Chemical Society.
J. R. Pearson et al., “Vinylindenes and Some Heteroanalogues in the Diels-Alder Reaction. IX 3-Vinylbenzofuran and 1,4-Naphthoquinone”, 1991, Vol. 44, p. 907-917, Aust. J. Chem.
S.V. Tolkunov et al., “Recyclization of 1,3-Dimethylbenzo[b]Furn[2,3-c]- and 1,3-Dimethylbenzo {b} Thieno{2,3-c}Pyrlium when Treated with Secondary Amines. Sytnethesis of 3-Dialkylamino Derivatives of Dibenzofuran and Dibenzothiphene”, 1998, vol. 34, No. 2, Chemistry of Heterocyclic Compound.
Doherty James B.
Shen Dong-Ming
Ayler Sylvia A.
Krovatin William
Merck & Co. , Inc.
Solola Taofiq A
LandOfFree
Ophthalmic compositions for treating ocular hypertension does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ophthalmic compositions for treating ocular hypertension, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ophthalmic compositions for treating ocular hypertension will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4112520