Ophthalmic compositions for lubricating eyes and methods for...

Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Ophthalmic preparation

Reexamination Certificate

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C514S057000, C514S912000

Reexamination Certificate

active

07045121

ABSTRACT:
Ophthalmic compositions include an ophthalmically acceptable carrier component, for example, an aqueous-based carrier, and a plurality of polyanionic component portions having different molecular weights. In one embodiment, the polyanionic component includes a first polyanionic component portion having a first molecular weight; and a second polyanionic component portion having a different second molecular weight. Each of the first and second polyanionic component portions is present in an amount effective to provide lubrication to an eye when the composition is administered to an eye. Methods of making and using such compositions are also disclosed.

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patent: 5460834 (1995-10-01), Bhagat
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patent: 5858346 (1999-01-01), Vehige et al.
patent: 0590786 (1994-04-01), None
patent: WO 0101959 (2001-01-01), None
Aqualon® CMC, Physical and Chemical Properties, Hercules Incorporated, 1999.
Abstract Submitted to ARVO for Conference held Nov. 30, 2001: The Effect of Differenct CMC Materials in Artificial Tears in the Tear Layer on Contrast Sensitivity.
LaMotte et al. “The effect of artificial tears with different CMC formulations on contrast sensitivity”, ARVO Annual meeting abstract search and program planner, vol. 2002, 2002 pg abstract No. 3151.
Allergan “Refresh lubricant eyedrops” retrieved on Apr. 3, 2003 from: www.drugstore.com/qxp72838—333181—seaspider/allergan/refresh—liquigel—lubricant—eye—drops.htm.
Simmons P A, “Refresh Liquigel (TM): A new approach to the treatment of persistent dry eye”, Practical Optometry 2002 Canada, vol. 13, No. 2, 2002, pp. 68-71.

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