Ophthalmic compositions comprising emedastine and methods for th

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514912, A61K 3150

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active

054419581

ABSTRACT:
Topical ophthalmic compositions comprising 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole and its ophthalmically acceptable acid addition salts have been found to be useful in treating allergic conjunctivitis and related ailments.

REFERENCES:
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patent: 5192780 (1993-03-01), York et al.
Miller, J. et al., "Antazoline phosphate and naphazoline hydrochloride, singly and in combination for the treatment of allergic conjunctivitis-a controlled, double-blind clinical trial," Ann. Allergy., 35:81-86 (1975).
Vandewalker, M. L., et al., "Efficacy of Vasocon-A and its components with conjunctival provaction testing (CPT)," J. Allergy Clin. Immunol., 83:302 (1989).
Abelson, M. B., et al., "Effects of topically applied ocular decongestant and antihistamine," Am. J. Ophthalmol., 90:254-257 (1980).
DeChant, K. L. and K. L. Goa, "Levocabastine. A Review of its pharmaceutical properties and therapeutic potential as a topical antihistamine in allergic rhinitis and conjunctivitis," Drugs, 41:202-224 (1991).
Berdy et al., "Allergic conjunctivitis: A survey of new antihistamines," J. Ocular Pharmacol., 7:313-324 (1991).
Yanni et al., "Effect of Lodoxamide on in vitro and in vivo conjunctival immediate hypersensitivity responses in rats," Int. Arch. Allergy Immunol., 101:102-106 (1993).
Dunnett, C. W., "A multiple comparison procedure for comparing treatments with a control," J. Am. Stat. Assoc., 50:1096-1121 (1955).
Bliss, C. and E. Gjorgy, Vitamin Methods, vol. 2, pp. 445-610, Academic Press, Inc. New York (1951).

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