Ophthalmic composition for lowering intraocular pressure

Details Ophthalmic composition for lowering intraocular pressure Ophthalmic composition for lowering intraocular pressure

1995-01-24

1996-07-23

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514431, A61K 31495, A61K 3139

Patent

active

055389740

ABSTRACT:
An ophthalmic composition comprising a compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each a hydrogen, a halogen, a hydroxyl, a lower alkyl or a lower alkoxy, R.sup.3 and R.sup.4 are each a hydrogen, an optionally substituted lower alkyl, an optionally substituted cycloalkyl or an optionally substituted aralkyl, or form, together with the adjacent nitrogen atom, an optionally substituted ring, X is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally esterified or amidized carboxyl, Y is >C.dbd.O or >CH--OR.sup.5 wherein R.sup.5 is a hydrogen, an acyl or an optionally substituted carbamoyl, m is an integer of from 0 to 2, and n is an integer of from 1 to 6, or a salt thereof, and a method for the treatment of glaucoma, comprising administering said compound or a salt thereof.

REFERENCES:
Mermoud et al., KLIN. MBL. AUGENHEICK, vol. 198 (1991) pp. 332-334.
Mermoud et al., Ophtalmologie, vol. 6 (1992) pp. 411-413.
Chang et al, Medline Abstracts, abstract #89124670, 1985.
Krootila et al., Chemical Abstracts, vol. 108, No. 17, abstract #143438h, p. 76, 1988.

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