Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2002-07-22
2008-01-22
Fay, Zohreh (Department: 1618)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S912000
Reexamination Certificate
active
07321000
ABSTRACT:
An ophthalmic pharmaceutical composition containing acetylcysteine as the active ingredient having a mucolitic action, suitable for administration in eyedrops, where N-acetyl-cysteine is neutralised with base DEAE-dextrane in order to reach pH levels preferably between 6.0 and 7.5, and having a physiologically acceptable osmolarity less than 320 mOsm/kg. The presence of a neutralising agent for N-acetyl-cysteine that does not negatively affect the composition osmolarity allows the formulation to be isotonic or even hypotonic, thus avoiding the irritative and potentially damaging effects of previous ophthalmic products containing N-acetyl-cysteine.
REFERENCES:
patent: 5256420 (1993-10-01), Tsao et al.
patent: 0 551848 (1993-07-01), None
patent: 1 151 755 (1986-12-01), None
Boldrini Enrico
Burgalassi Susi
Chetoni Patrizia
Giannaccini Boris
Saettone Marco Fabrizio
Arent & Fox LLP
Farmigea S.p.A.
Fay Zohreh
LandOfFree
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