Oomycete FtsZ-mt as a target for oomycete-specific...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007100

Reexamination Certificate

active

06852498

ABSTRACT:
The invention relates to a genes isolated from an oomycete that encode homologs of an FtsZ protein. The invention includes methods of using these proteins to discover new antimicrobials, based on the essentiality of the gene for normal growth and development. The invention can also be used in screening assays to identify inhibitors that are potential antimicrobials. These antimicrobials may be used in a method of controlling oomycete growth on crop plants and seeds.

REFERENCES:
patent: 5981836 (1999-11-01), Osteryoung
patent: 6197300 (2001-03-01), Fueyo et al.
Desnottes, Trends in Biotechnology, vol. 14 pp. 134-140 (1996).*
Berendsen, Science vol. 282, pp. 642-643 (1998).*
Beech et al., Mitochondrial FtsZ in a Chromophyte Alga,Science, 287:1276-1279 (2000), Database Entry Q9M7M6.
Beech et al., “FtsZ and Organelle Division in Protists”,Protist, 151: 11-16 (2000).
Kamoun et al., “Initial assessment of gene diversity for the oomycete pathogen Phytophthora infestans based on expressed sequences,”Fungal Genet. Biol., 28: 94-106 (1999), Database Entry BE777302.
Margolin, William, “Organelle division: Self-assembling GTPases caught in the middle”,Current Biology, 10: R328-R330 (2000).
Beech et al., “Mitochondrial FtsZ in a Chromophyte Alga,”Science, vol. pp. 1276-1279, Feb. 18, 2000.

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