Onset of force development as a marker of thrombin generation

Details Onset of force development as a marker of thrombin generation Onset of force development as a marker of thrombin generation

2007-04-10

2007-04-10

Gitomer, Ralph (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

C435S069600, C436S069000

Reexamination Certificate

active

10405472

ABSTRACT:
Platelet contractile force (PCF) is used as a surrogate marker of thrombin generation. PCF generation occurs concomitant with the burst of prothrombin fragment F 1+2 release. The time between assay start and PCF onset is identified as the thrombin generation time (TGT), and is used in assessing risk of bleeding, in diagnosing various disorders, and in monitoring the effects of pharmaceutical and other treatments. TGT is prolonged in clotting factor deficiencies and in the presence of direct and indirect thrombin inhibitors. TGT shortens to normal with clotting factor replacement and shortens with administration of rVIIa. TGT is short in thrombophilic states such as coronary artery disease, diabetes and thromboangiitis obliterans and prolongs toward normal with oral and intravenous anticoagulants.

REFERENCES:
Carr et al. Am J Med Sci 1991;302(1)13-18.
Jen et al. Cell Motility 1982;2:445-455.
Greilich et al. Am J Med Sci 1994;307(1)15-20.

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