Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1991-03-07
1997-07-15
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
5303915, A61K 5110, C07K 1600
Patent
active
056484712
ABSTRACT:
A one vial method for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is disclosed. The method comprises contacting an antibody mixture comprised of a sulfhydryl containing antibody or antibody fragment and a reducing agent with technetium-99m in an oxidized state. In a preferred embodiment, the antibody mixture further contains a water soluble ligand. A one vial kit for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is also disclosed.
REFERENCES:
patent: 4113850 (1978-09-01), Benes
patent: 4305922 (1981-12-01), Rhodes
patent: 4421735 (1983-12-01), Haber et al.
patent: 4424200 (1984-01-01), Crockford et al.
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4478815 (1984-10-01), Burchiel et al.
patent: 4652440 (1987-03-01), Paik et al.
patent: 4659839 (1987-04-01), Nicolotti et al.
patent: 4668503 (1987-05-01), Hnatowich
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4732974 (1988-03-01), Nicolotti et al.
patent: 4877868 (1989-10-01), Reno et al.
patent: 5053493 (1991-10-01), Pak et al.
Khaw et al., "Myocardial Infarction Imaging of Antibodies to Canine Myosin with Indium-111-Diethylenetriamine Pentaacetic Acid," Science 209:295-297 (1980).
Krejcarek and Tucker, "Covalent Attachment of Chelating Groups to Macromolecules," Biochem. Biophys. Res. Commun., 77:581-585 (1977).
Childs an Hnatowich, "Optimum Conditions for Labeling of DTPA-Coupled Antibodies with Technetium-99m," J. Nucl. Med., 26:293-299 (1985).
PCT Patent Application PCT/AU87/04164, I. McKenzie et al., "Technetium-Antibody Conjugate," Jul. 16, 1987.
Fritzberg et al., "Radiopharmaceutical chemistry V: Antibodies", J. Nucl. Med., 27:957-958 (1986).
Khaw et al., "Technium-99m Labeling of Antibodies to Cardiac Myosin Fab and to Human Fibrinogen," The Journal of Nuclear Medicine, 23 (11): 1011-1019 (1982).
Eckelman and Paik, "Comparison of .sup.99m Tc and .sup.111 In Labeling of Conjugated Antibodies," Nuclear Medicinal Biology, 13(4) 335-343 (1986).
Paik et al., "The Labeling of High Affinity Sites of Antibodies with 99m Tc," International Journal of Nuclear Medicinal Biology, 12 (1): 3-8 (1985).
Schwarz et al., "A Novel Approach to Tc-99m Monoclonal Antibodies," J. Nucl. Med., 28: 721 (1987).
Steinstrasser et al., "A Novel Tc-99m Labelled Antibody for in vivo Targeting of Granulocytes," J. Nucl. Med., 29: 925 (1988).
Buttram Scott
Dean Richard T.
Lister-James John
Pak Koon Yan
Centocor, Inc.
Russel Jeffrey E.
LandOfFree
One vial method for labeling antibodies with Technetium-99m does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with One vial method for labeling antibodies with Technetium-99m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and One vial method for labeling antibodies with Technetium-99m will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1493156