One-use device for directly taking a sample of expired air from

Details One-use device for directly taking a sample of expired air from One-use device for directly taking a sample of expired air from

1996-09-04

1998-01-27

Bahr, Jennifer

Surgery

Truss

Pad

215228, 215247, 215248, 215 43, 215 45, 215307, G01N 3300, A61R 508

Patent

active

057113068

DESCRIPTION:

BRIEF SUMMARY
The present invention relates to a one-use device which enables a sample of expired air to be taken directly from a subject with a view to subsequent analysis in the laboratory, and more particularly an isotopic analysis of the .sup.13 CO.sub.2 within the framework of the so-called "Breath Test" method.
It is known that the variation of the isotopic enrichment with carbon 13 of the carbon dioxide (CO.sub.2) contained in the air expired by a subject, after administration to the latter of a specific substrate enriched with .sup.13 C, enables clinical investigations for final diagnosis to be made. In fact, the measurement bears on very slight variations, with the result that the mode of taking the gaseous samples and the material used to that end are of primordial importance, making it impossible to employ the systems of sampling by multi-layer plastic bags usually used for taking samples of gas in the atmosphere.
In practice, glass tubes, pre-packed in vacuo, are generally employed, which are normally used for taking blood samples, but experiments carried out show that this type of recipient is not suitable for obtaining reliable samples of expired air. Manipulations are complex since the subject must blow in and fill an air-tight bag, from which a volume of air must be transferred immediately in the tube. Filling of the tube depends on the level of vacuum prevailing inside it, which level can never be guaranteed.
It is a principal object of the present invention to overcome these drawbacks, with the aid of the special sampling device forming the subject matter thereof.
This device comprises, in combination: whose volume corresponds to that desired of the sample to be taken; obturation of the upper; open part thereof; which stopper is fast with a lateral tube whose inner opening is obturated by the wall of the recipient when said stopper has been brought to the lower axial position of seal; into one of the ends of this cannula, while the opposite end which opens freely in the recipient is provided with a blind, annular, projecting stop; the blind annular stop of the cannula once the latter has been displaced axially by the operator pulling; pipe and which is arranged to indicate to the operator that a sufficient volume of expired air has passed through and scavenged the recipient.
The accompanying drawings, given by way of example, will enable the invention, the characteristics that it presents and the advantages that it is capable of procuring, to be more readily understood.
FIG. 1 is an axial section illustrating the general arrangement of a sampling device according to the invention.
FIG. 2 partially reproduces on a larger scale the section of FIG. 1, after the stopper has been lowered and the insufflation cannula pulled out.
The sampling device illustrated firstly comprises a rigid recipient formed by a glass tube 1 of conventional type, of which the open upper part comprises a threading 1a, while the top wall 1b is provided to be plane in order to cooperate with a perforatable membrane 2.
With this tube 1 there is associated a stopper 3 whose cylindrical skirt presents an upper threading 3a adapted to cooperate with threading 1a; the bottom of this skirt is profiled at 3b to hold an O-ring 4, thus applied tightly against the outer wall of the tube 1.
It should be observed that the skirt of the stopper 3 is fast with a lateral tube 3c oriented obliquely upwardly. The axial bore of this tube 3c presents two diameters so as to define an annular shoulder which holds an O-ring 5, whose function will be seen hereinbelow, in place.
In tube 3c there is engaged to slide axially a cannula 6 which, in the immediate vicinity of its lower end enclosed in the tube 1, is pierced laterally with at least one slot 6a for communication. Therebelow, the cannula 6 is equipped with a blind annular stop 7 which thus defines a projecting part; between the stop 7 and the slot 6a there is provided an annular incipient break 6b.
The free upper end of the cannula 6 is provided with a cone 6c allowing it to be connected to an insuf

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