Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-07-20
1996-11-26
Peselev, Elli
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 72, 536 74, C07H 100
Patent
active
055787134
ABSTRACT:
The disclosure relates to a new process for the synthesis of the macrolide antibiotic dirithromycin in crystalline form. The process is carried out in a single reaction vessel whereby an acetal dissolved in acetonitrile, in the presence of an acid catalyst, is hydrolyzed to the related hemiacetal which then reacts directly with erythromycylamine to form crystalline dirithromycin.
REFERENCES:
patent: 4048306 (1977-09-01), Maier et al.
patent: 4438109 (1984-03-01), Umezawa et al.
patent: 4794173 (1988-12-01), Umezawa et al.
Counter et al, Antimicrobial Agents and Chemotherapy, Jun. 1991, pp. 1116-1121.
Luger and Maier, Molecular structure of 9-deoxy-11-deoxy-9-11-(imino(2-(2-methoxyethoxy)ethylidene)oxy)-(9S)-eryth romycin, a new erythromycin derivative, Journal of Crystal and Molecular Structure, 9:329-338 (1979).
Dirithromycin, Drugs of the Future 14:112-115 (1989).
Firl et al., Epimerization of erythromycin derivatives, Journal of Antibiotics 43:1271-77 (1990).
Counter, et al., "Synthesis and Antimicrobial Evaluation of Dirithromycin", Antimicrobial Agents and Chemotherapy, vol. 35, No. 6, pp. 1116-1126, Jun., 1991.
Cantrell Paul R.
Eli Lilly and Company
Jones Joseph A.
Page Kathleen R. S.
Peselev Elli
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