One-step process for preparation of N-(4-substituted pyrazolyl)

Details One-step process for preparation of N-(4-substituted pyrazolyl) One-step process for preparation of N-(4-substituted pyrazolyl)

1995-10-02

1996-11-05

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483647, C07D23138

Patent

active

055719260

ABSTRACT:
In the production of 1H-pyrazolo[1,5-b] [1,2,4]triazole couplers, substituted 3-amino-pyrazole compounds add to suitable organic nitriles in the presence of an acidic condensing agent such as aluminum chloride, stannic chloride or boron trifluoride to directly produce desired amidine intermediates in good yields, avoiding the generation of moisture sensitive intermediate imidate esters. Moreover, the availability of oxidation techniques to convert amidines to 1H-pyrazolo[1,5-b] [1,2,4]triazole couplers in a single step makes it possible to produce these couplers in a total of two steps compared to conventional multi-step synthetic schemes.

REFERENCES:
patent: 4753870 (1988-06-01), Takada et al.
patent: 4814262 (1989-03-01), Sugita et al.
patent: 4880733 (1989-11-01), Kaneko
patent: 4945034 (1990-07-01), Tanji et al.
Sambaiah et al, Synthesis, (1990) pp. 422-424.

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