One step oligochromatographic device and method of use

Details One step oligochromatographic device and method of use One step oligochromatographic device and method of use

2011-04-26

2011-04-26

Griffin, Walter D (Department: 1774)

Chemistry: analytical and immunological testing

Including chromatography

C436S514000, C435S006120, C435S004000

Reexamination Certificate

active

07932093

ABSTRACT:
The present invention relates to methods and devices for detecting one or more analytes in a biological sample, preferably a clean liquid sample. This invention in particular relates to improved rapid tests such as “dipsticks”, “lateral flow” devices and “flow-through” devices. The invention in particular relates to oligochromatographic devices that make use of a peptide- or hapten-coupled oligonucleotide and a reagent specifically recognizing the hapten or peptide and a conjugated probe that hybridizes specifically to a target sequence. It allows to detect specifically the presence of a polynucleotides directly or after molecular amplification steps with the use of a specific genuine internal control and a chromatographic control.

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