One-step method for attachment of biomolecules to substrate surf

Coating processes – Medical or dental purpose product; parts; subcombinations;... – Implantable permanent prosthesis

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427 225, 427 227, 427 228, 427 23, 427 231, 427537, A61L 1500, A61L 2700, H05H 100

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active

061433543

ABSTRACT:
A method of modifying the surface characteristics of a substrate, particularly a polymeric material. The method involves grafting ethylenically unsaturated monomers and attaching biomolecules, such as heparin, to the surface of the substrate, such as a polymeric material, in one step using an oxidizing metal, such as ceric ions.

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Park et al., "Heparin immobilization onto segmented polyurethaneurea surfaces--effect of hydrophilic spacers," Journal of Biomedical Materials Research, 22, 977-992 (1988).

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