Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1989-06-27
1992-04-14
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435224, 435230, 435 47, C12N 978, C12N 980, C12N 989, C12P 3500
Patent
active
051048000
ABSTRACT:
A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and derivatives with a cephalosporin C amidase enzyme of a recited sequence, the DNA encoding said enzyme, and expression thereof in a suitable host, e.g., Bacillus species under the control of a suitable promoter.
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Crawford Mark S.
Finkelstein David B.
Rambosek John A.
Marx Irene
Merck & Co. , Inc.
Pfeiffer Hesna J.
Robinson Douglas W.
Speer Raymond M.
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