One post synthesis of 2-oxazolidinone derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

06909005

ABSTRACT:
The present invention provides an improved (S)-4-{[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone product which is prepared by a method which comprises: a) forming a carbamate of formula (III), from methyl 4-nitro-(L)-phenylalaninate hydrochloride; b) reducing the compound of formula (III) to give the compound of formula (IV); c) reducing the methyl ester grouping in the compound of formula (IV) to give the compound of formula (V); d) ring closure of the compound of formula (V) to give the compound of formula (VI); e) diazonium salt formation from the compound of formula (VI) followed by reduction to give the compound of formula (VII); f) Fischer reaction of the compound of formula (VII) to give (S)-4-{[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone.

REFERENCES:
patent: 5399574 (1995-03-01), Robertson et al.
patent: 5466699 (1995-11-01), Robertson et al.
patent: 5863935 (1999-01-01), Robertson et al.
patent: 5962486 (1999-10-01), Blade et al.
patent: 0313 397 (1989-04-01), None
patent: 91/18897 (1991-12-01), None
patent: 95/20588 (1995-08-01), None
Physics and Chemistry of the Organic Solid State, Sloan, (1963).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

One post synthesis of 2-oxazolidinone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with One post synthesis of 2-oxazolidinone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and One post synthesis of 2-oxazolidinone derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3492048

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.