Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-07-17
2007-07-17
Shibuya, Mark L. (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S287100, C435S288700, C435S091500, C435S091500, C435S091500, C435S091500
Reexamination Certificate
active
09535300
ABSTRACT:
Linear arrays of chemosensors or chemical compounds are supported by an optical fiber that allows one to rapidly assay the entire array using changes in optical properties such as fluorescence. The location of the agent along the fiber determines the identity of the agent in these linear arrays. Combinatorial libraries may be constructed on the fiber as well as assayed on the optical fiber. A system and method of analyzing the entire array of agents on an optical fiber using a light source, an optical fiber, and a detector are also described. The time delay between the excitation and detection determines the location being assayed along the fiber and therefore the identity of the agent being assayed. The present invention may find uses in the medical, pharmaceutical, environmental, defense, and food industries.
REFERENCES:
patent: 4689405 (1987-08-01), Frank et al.
patent: 4848687 (1989-07-01), Myers et al.
patent: 5030841 (1991-07-01), Wampfler
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5510270 (1996-04-01), Fodor et al.
patent: 5527681 (1996-06-01), Holmes
patent: 5547839 (1996-08-01), Dower et al.
patent: 5565324 (1996-10-01), Still et al.
patent: 5585275 (1996-12-01), Hudson et al.
patent: 5599695 (1997-02-01), Pease et al.
patent: 5688696 (1997-11-01), Lebl
patent: 5807754 (1998-09-01), Zambias et al.
patent: 5837196 (1998-11-01), Pinkel et al.
patent: 6037186 (2000-03-01), Stimpson
patent: 6040191 (2000-03-01), Grow
patent: 6156494 (2000-12-01), Adams et al.
patent: 0 385 433 (1990-09-01), None
patent: WO 96/16078 (1996-05-01), None
patent: WO 99/42605 (1999-08-01), None
Arkles, “Tailoring Surfaces With Silanes”Chemtech7:766-778, 1977.
Blair et al., “Study of Analyte Diffusion into a Silicone-Clad Fiber-Optic Chemical Sensor by Evanescent Wave Spectroscopy”Appl. Spectr.49:1636-1645, 1995.
Brenner et al., “Encoded combinatorial chemistry”Proc. Natl. Acad. Sci. USA89:5381-5383, 1992.
Briceño et al., “A Class of Cobalt Oxide Magnetoresistance Materials Discovered with Combinatorial Synthesis”Science270:273-275, 1995.
Browne et al., “Intrinsic Sol-Gel Clad Fiber-Optic Sensors with Time-Resolved Detection”Analytical Chemistry68:2289-2295, 1996.
Bunin et al., “The Combinatorial Synthesis and Chemical and Biological Evaluation of a 1,4-Benzodiazepine Library”Proc. Natl. Acad. Sci. USA91:4708-4712, 1994.
Colin et al., “The Effect of Mode Distribution on Evanescent Field Intensity: Applications in Optical Fiber Sensors”Appl. Spectrosc.45:1291-1295, 1991.
Colin et al., “The Effect of Length and Diameter on the Signal-to-Noise Ratio of Evansecent Field Absorption Fiber-Optic Sensors”Appl. Spectrosc.46:1129-1133, 1992.
Czarnik, “Encoding strategies in Combinatorial chemistry”Proc. Natl. Acad. Sci. USA94:12738-12739, 1997.
Czarnik, “Encoding methods for Combinatorial chemistry”Current Opinion in Chemical Biology1:60-66, 1997.
Danielson et al., “A combinatorial approach to the discovery and optimization of luminescent materials”Nature389:944-948, 1997.
DeWitt et al., “Diversomer™ Technology: Solid Phase Synthesis, Automation, and Integration for the Generation of Chemical Diversity”Drug Development Research33:116-124, 1994.
Devlin et al., “Random Peptide Libraries: A Source of Specific Protein Binding Molecules”Science249:404-406, 1990.
Egami et al., “Evanescent Wave Spectroscopic Fiber Optic pH Sensor”Opt. Communc.122:122-126, 1996.
Fodor,Faseb J.11:A879, 1997. Abstract 121.
Fodor, “Massively Parallel Genomics”Science277:393-395, 1997.
Fodor et al, “Light-Directed, Spatially Addressable Parallel Chemical Synthesis”Science251:767-773, 1991.
Frank et al., “Spot-Synthesis: An Easy Technique for the Positionally Addressable, Parallel Chemical Synthesis on a Membrane Support”Tetrahedron48(42):9217-9232, 1992.
Freier et al., “Deconvolution of Combinatorial Libraries for Drug Discovery: A Model System”J. Med. Chem.38:344-352, 1995.
Furka et al, “General method for rapid synthesis of multicomponent peptide mixtures”Int. J. Peptide Protein Res.37:487-493, 1991.
Furka et al., “String Synthesis. A Spatially Addressable Split Procedure”J. Comb. Chem.2(3): 220-223, 2000.
Ge et al. “Fiber-Optic pH Sensor Based on Evanescent Wave Absorption Spectroscopy”Anal. Chem.65:2335-2338, 1993.
Gennari et al.,Liebigs Ann./Recueil.637-647, 1997.
Geysen et al., “A prioriDelineation of a Peptide Which Mimics a Discontinuous Antigenic Determinant”Mol. Immun.23(7):709-715, 1986.
Gravert et al., “Organic Synthesis on Soluble Polymer Supports: Liquid-Phase Methodologies”Chem. Rev.97:489-509, 1997.
Gupta et al., “Fiber-Optic Evanescent Field Absorption Sensor: A Theoretical Evaluation”Fiber Integrated Opt.13:443-443, 1994.
Gupta et al., “Experimental Studies on the Response of the Fiber Optic Evanescent Field Absorption Sensor”Fiber and Integrated Optics17:63-73, 1998.
Houghten et al., “Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery”Nature354:84-86, 1991.
Konings et al., “Deconvolution of Combinatorial Libraries for Drug Discovery: Theorectical Comparison of Pooling Strategies”J. Med. Chem.39:2710-2719, 1996.
Krch{hacek over (n)}ák et al., “Noninvasive Continuous Monitoring of Solid-Phase Peptide Synthesis by Acid-Base Indicator”Collect. Czech. Chem. Commun.53:2452-2548, 1988.
Kricka, “Selected Strategies for Improving Sensitivity and Reliability of Immunoassays”Clin. Chem.40(3):347-357, 1994.
Lam et al., “A new type of synthetic peptide library for identifying ligand-binding activity”Nature354:82-84, 1991.
Lam et al., “The ‘One-Bead-One-Compound’ Combinatorial Library Method”Chem. Rev.97:411-448, 1997.
Liang et al., “Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library”Science274:1520-1522, 1996.
MacBeath et al., “Printing Small Molecules as Microarrays and Detecting Protein-Ligand Interactions en Masse”J. Am. Chem. Soc.121:7967-7968, 1999.
Marcuse, “Launching Light into Fiber Cores from Sources Located in the Cladding”J. Lightwave Technolog.6(8) :1273-1279, 1988.
Messica et al., “Theory of Fiber-Optic, Evanescent-Wave Spectroscopy and Sensors”Appl. Opt.35:2274-2284, 1996.
Michael et al. “Randomly Ordered Addressable High-Density Optical Sensor Arrays”Analytical Chemistry70:1242-1248, 1998.
Nefzi et al., “The Current Status of Heterocyclic Combinatorial Libraries”Chem Rev.97:449-472, 1997.
Ohlmeyer et al., “Complex synthetic chemical libraries indexed with molecular tags”Proc. Natl. Acad. Sci. USA90:10922-10926, 1993.
Pilevar et al., “Tapered Optical Fiber Sensor Using Near-Infrared Fluorophores to Assay Hybridization”Anal. Chem.70:2031-2037, 1998.
Pirrung, “Spatially Addressable Combinatorial Libraries”Chem. Rev.97:473-488, 1997.
Radhakrishnan et al. “Fiber Optic Sensor Based on Evanescent Wave Absorption”Opt. Eng.32:692-694, 1993.
Reddington et al., “Combinatorial Electrochemistry: A Highly Parallel, Optical Screening Methods for Discovery of Better Electrocatalysts”Science280:1735-1737, 1998.
Sapolsky et al.,Genetic Analysis: Biomolecular Engineering14:187-192, 1999.
Schmidt et al., “Molecular Interaction Between theStrep—tag Affinity Peptide and its Cognate Target, Streptavidin”J. Mol. Biol.255:753-766, 1996.
Schwabacher et al., “Fourier Transform Combinatorial Chemistry”J. Am. Chem. Soc.121(37):8669-8670, 1999.
Senkan, “High-throughtput screening of solid-state catalyst libraries”Nature394:350-353, 1998.
Smith et al, “Neckl
Geissinger Peter
Schwabacher Alan W.
Baker C. Hunter
Choate Hall & Stewart
Herschbach Jarrell Brenda
Shibuya Mark L.
WiSys Technology Foundation Inc.
LandOfFree
One-dimensional arrays on optical fibers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with One-dimensional arrays on optical fibers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and One-dimensional arrays on optical fibers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3738799