One carbon homologation of carbohydrates by transcyanohydrinatio

Details One carbon homologation of carbohydrates by transcyanohydrinatio One carbon homologation of carbohydrates by transcyanohydrinatio

1987-07-13

1990-02-13

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435128, 536 553, 558351, 558451, 558410, C12P 1926

Patent

active

049006673

ABSTRACT:
A method of homologating monosaccharides via their cyanohydrins utilizes transcyanohydrination across a phase boundary from a water-insoluble donor cyanohydrin dissolved in an organic, water-immiscible solvent to an aqueous solution of a receptor monosaccharide. This heterogeneous transcyanohydrination can be incorporated into a cyclic process where the cyanide donor is enzymatically regenerated via enzyme catalyed addition of HCN to a suitable aldehyde. The latter process can be made continous or semicontinuous by immobilization of the enzyme.

REFERENCES:
patent: 2259167 (1941-10-01), Kung
patent: 4048210 (1977-09-01), Davis
patent: 4246189 (1981-01-01), Kleemann et al.
W. Becker, H. Freund, and E. Pfeil, Angew. Chem. Internat. Edit., 4, 1079 (1965).

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