Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1997-10-24
1999-09-28
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
A61F 202
Patent
active
059584424
ABSTRACT:
Oncostatin M is employed in methods to treat acute and chronic gastrointestinal inflammation, rheumatoid arthritis and multiple sclerosis.
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Zarling et al., "Oncostatin M: A Growth Regulator Produced by Differentiated Histiocytic Lymphoma Cells," PNAS 83:9739-9743 (1986).
Malik et al., "Molecular Cloning, Sequence Analysis and Functional Expression of a Novel Growth Regulator, Oncostatin M," Mol. Cell. Biol. 9:2847-2853 (Jul., 1989).
Linsley et al., "Identification and Characterization of Cellular Receptors for the Growth Regulator, Oncostatin M," J. Biol. Chem. 264:4282-289 (1989).
Rose et al., "Oncostatin M is a Member of a Cytokine Family that Includes Leukemia-Inhibitory Factor, Granulocyte Colony-Stimulating Factor, and Interleukin 6," PNAS 88:8641-8645 (1991).
Gearing et al., "Oncostatin M Binds the High Affinity Leukemia Inhibitory Factor Receptor," New Biol., 4:61-65 (1992).
Richards et al., "Recombinant Oncostatin M Stimulates the Production of Acute Phase Proteins in HepG2 Cells and Rat Primary Hepatocytes in Vitro," J. Immunol. 148:1731-1736 (1992).
Thoma et al., "Oncostatin M and Leukemia Inhibitory Factor Trigger Overlapping and Different Signals Through Partially Shared Receptor Complexes," J. Biol. Chem. 269:6215-6222 (1994).
Moseley et al., "Dual Oncostatin M (OSM) Receptors," J. Biol. Chem. 271:32635-43 (1996).
Brown Thomas J.
Wallace Philip M.
Azpuru Carlos A.
Bristol--Myers Squibb Company
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