Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-06-16
1995-09-19
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 721, 435960, 530351, G01N 3374, G01N 3368, G01N 3360, C07K 1300
Patent
active
054515068
ABSTRACT:
Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their preparation and methods for their use are provided. The compositions may be prepared by isolation from natural sources, or by recombinant means in either prokaryotic or eukaryotic host cells. In addition, the DNA and polypeptide sequences for Oncostatin M are disclosed. The compositions find use in modulating growth of cells, in particular inhibition of tumor cell proliferation, and stimulation of normal cell growth, especially cells involved in hematopoiesis. Cell growth inhibition compositions may additionally include an adjunctive agent comprising at least one of a transforming growth factor, tumor necrosis factor, or an interferon. Receptors having high affinity for Oncostatin M may additionally be used to screen polypeptides for Oncostatin M-like activity. Methods for use of antibodies to the compositions and probes specific for Oncostatin M mRNA as a means for detecting tumor cells are also provided.
REFERENCES:
Zarling et al; "Oncostatin M: A Growth Regulator Produced By Differentiated . . . ," Proc Natl Acad Sci 83:9739-9743 (1986).
Linsley et al; "Identification And Charactorization of Cellular Receptors . . . ," J Biol. Chem 264:4287-4289 (1989).
Hanson Marcia B.
Linsley Peter S.
Marquardt Hans
Shoyab Mohammed
Zarling Joyce M.
Nucker Christine M.
Oncogen Limited Partnership
Woodward M. P.
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