Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-09-08
1999-11-30
Patterson, Jr., Charles L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303879, C07K 1640
Patent
active
059945133
ABSTRACT:
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
REFERENCES:
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Cano, E., et al., Parallel signal processing among mammalian MAPKs, TIBs, vol. 20, (1995), 117-122.
Hibi, M., et al., Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain, Genes and Development 7:2135-2148 (1993).
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Adler et al., Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: Regulation by the N-terminal & domain, Proc. Natl. Acad. Sci. USA., vol. 89, pp. 5341-5345, Jun. 1992, Biochemistry.
Boulton, et al., ERKs: A Family of Protein-Serine/Threonine Kinases That Are Activated and Tyrosine Phosphorylated in Response to Insulin and NGF, Cell, vol. 65, pp. 663-675, May 17, 1991.
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Anderson et al., Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase, Nature, vol. 343, Feb. 15, 1990, pp. 651-653.
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Karin Michael
Lin Anning
Haile Lisa A.
Patterson Jr. Charles L.
University of California
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