Oncoprotein protein kinase

Details Oncoprotein protein kinase Oncoprotein protein kinase

1994-07-18

1997-01-14

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 435194, 536 232, C12N 1554, C12N 1574

Patent

active

055938841

ABSTRACT:
An isolated polypeptide (JNK) characterized by having a molecular weight of 46kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

REFERENCES:
Derijard, B., et al. (1994) Cell 76, 1-20.
Cano, E., et al. (1995) Tibs 20, 117-122.
Hibi, M., et al. (1993) Genes and Development 7, 2135-2148.
Minden, A., et al. (1994) Mol. Cell. Biol. 14 (10), 6683-6688.
Pulverer B. J. et al. (1991) Nature 353, 670-674.
Adler, V., et al. (1992) Proc. Natl, Acad. Sci. USA 89, 5341-5345.
Boulton, T. G., et al. (1991) Cell 65, 663-675.
Boulton T. G. et al, (1990) Science 249, 64-67.
Kyriakis, J. M., et al. (1990) J. Biol. Chem, 265 (28) 17355-17363.
Suggs, S. V., et al, (1981) Proc. Natl. Acad. Sci. USA 78(11), 6613-6617.
Lee, C. C., et al, (1988) Science 239, 1288-1290.

Affiliated with

Also associated with

Rating

Oncoprotein protein kinase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oncoprotein protein kinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oncoprotein protein kinase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1387585