Oncoprotein protein kinase

Details Oncoprotein protein kinase Oncoprotein protein kinase

1997-02-13

1998-09-08

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435194, C12Q 148

Patent

active

058043993

ABSTRACT:
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

REFERENCES:
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Cano, E., et al., Parallel signal processing among mammalian MAPKs, TIBS, 20, (1995), 117-122.
Hibi, M., et al., Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain, Genes and Development 7:2135-2148 (1993).
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