Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2007-12-11
2007-12-11
Campell, Bruce R. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S002000, C435S007210, C514S04400A, C424S093100
Reexamination Certificate
active
10602024
ABSTRACT:
The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death of these cells. Therefore, a cell which becomes neoplastic due to, at least in part, elevated ras pathway activities can be diagnosed by its susceptibility to reovirus replication. This invention can further be applied, using other oncolytic viruses, to the diagnosis and/or treatment of other tumors, such as interferon-sensitive tumors, p53-deficient tumors and Rb-deficient tumors. Kits useful in the diagnosis or treatment disclosed herein are also provided.
REFERENCES:
patent: 5670330 (1997-09-01), Sonenberg et al.
patent: 6777177 (2004-08-01), Rubin et al.
patent: 2003/0138405 (2003-07-01), Fueyo et al.
patent: 2003/0165465 (2003-09-01), Roberts et al.
patent: 0 931 830 (1999-07-01), None
patent: WO 00/62735 (2000-10-01), None
patent: WO 01/19380 (2001-03-01), None
patent: WO 01/35970 (2001-05-01), None
patent: WO 01/37866 (2001-05-01), None
patent: WO 02/04596 (2002-01-01), None
patent: WO 02/39117 (2002-05-01), None
Strong, J.E. “The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus” EMBO (1998) vol. 17, No, 12, 3351-3362.
Norman, K.L. “Reovirus as a novel oncolytic agent” J. Clin. Invest. (Apr. 2000) vol. 105, No. 8, 1035-1038.
Norman et al. “Reovirus Oncolysis of Human Breast Cancer” Hum. Gene. Ther. (Mar. 2002) vol. 13, 641-652.
Coffey, M.C. “Reovirus Therapy of Tumors with Activated Ras Pathway” Science (Nov. 1998) vol. 282, 1332-1334.
Hirasawa, K. “Oncolytic Reovirus agains Ovarian and Colon Cancer” Cancer Res. (Mar. 2002) vol. 622, 1696-1701.
Norman et al. Proc. Natl. Acad. Sci. U S A. Jul. 27, 2004; 101(30): 11099-11104.
Smith et al. Exp. Opin. Invest. Drugs 2000, vol. 9, No. 2, pp. 311-327.
Einspahr et al. Cancer Epidemiol. Biomarkers Prev. 2006, vol. 15(8), pp. 1443-1450.
Norman K.L., et al., “Reovirus Oncolysis of Human Breast Cancer”,Human Gene Therapy13(5):641-652 (2002).
Portella, G. et al., “ONYX-015, an E1B Gene-Defective Adenovirus, Induces Cell Death in Human Anaplastic Thyroid Carcinoma Cell Lines”, 2002, The Journal of Clinical Endocrinology & Metabolism, vol. 87 (6), pp. 2525-2531.
Bischof JR. et al., “An Adenovirus Mutant that Replicates Selectively in p53-Deficient Human Tumor”,Science274(5286):373-376 (1996).
Bos, J, “ras oncogenes in human cancer: a review”,Cancer Res. 49:4682-4689 (1989).
Campbell, S.L. et al., “Increasing complexity of Ras signaling”,Oncogene17: 1395-1413 (1998).
Chandron and Nibert, “Protease cleavage of reovirus capsid protein mu1 and mu1C is blocked by alkyl sulfate detergents, yielding a new type of infectious subvirion particle”,J. of Virology72(1):467-75 (1998).
Chang et al.,J. Virol. 69:6605-6608 (1995).
Chang et al.,Proc. Natl. Acad. Sci. 89:4825-4829 (1992).
Chang et al.,Virol. 194:537-547 (1993).
Fueyo, J., et al., “A Mutant Oncolytic Adenovirus Targeting the Rb Pathway Produces Anti-Glioma Effect in Vivo”,Oncogene19(1):2-12 (2000).
Gutkind, J.S., “The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades”,J Biol Chem. 273:1839-1842 (1998).
Kawagishi-Kobayashi, M. et al.,Mol. Cell. Biol. 17:4146-4158 (1997).
Nemunaitis, J., “Oncolytic viruses”,J. Invest. New Drugs17:375-386 (1999).
Nibert, M.L., Schiff, L.A., and Fields, B.N., “Reoviruses and their replication”, pp. 1557-1596 inVirology(Fields et al., 3rd Edition), Lippencott-Raven Press, 1996.
Romano et al.,Mol. Cell. Bio. 18(12):7304-7316 (1998).
Sharp et al.,Virology250:302-315 (1998).
Smith, R.E., et al., “Polypeptide components of virions, top component and cores of reovirus type 3”,Virology, 39:791-800 (1969).
Smith, C.A. et al., “Correlations among p53, Her-2
eu, and ras overexpression and aneuploidy by multiparameter flow cytometry in human breast cancer: evidence for a common phenotypic evolutionary pattern in infiltrating ductal carcinomas”,Clin Cancer Res. 6(1):112-26 (2000).
Coffey Matthew C.
Thompson Bradley G.
Campell Bruce R.
Li Bao Qun
Oncolyties Biotech Inc.
LandOfFree
Oncolytic viruses as phenotyping agents for neoplasms does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oncolytic viruses as phenotyping agents for neoplasms, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oncolytic viruses as phenotyping agents for neoplasms will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3866361