Oncolytic adenovirus

Details Oncolytic adenovirus Oncolytic adenovirus

2008-07-08

2008-07-08

Paras, Jr., Peter (Department: 1632)

Chemistry: molecular biology and microbiology

Vector, per se

Reexamination Certificate

active

10303598

ABSTRACT:
Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.

REFERENCES:
patent: 5998205 (1999-12-01), Hallenbeck et al.
patent: 2001/0053352 (2001-12-01), Yu et al.
patent: WO 98/13508 (1998-04-01), None

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