Oncogene fusion protein peptide vaccines

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4241921, 4242771, 435 71, 435 724, 435325, 435366, 514 2, 514 12, 514 13, 514 14, 514 15, 530324, 530325, 530326, 530327, 530328, A61K 3900, C07K 700

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061563161

ABSTRACT:
Fusion-point spanning peptides, for example BCR-ABL fusion breakpoint peptides associated with chronic myelogenous leukemia (CML), bind major histompatibility complex molecules, such as HLA class I molecules, and induce cytotoxic T cell proliferation. The breakpoint peptides can be used as vaccines.

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Drexler, et al., Leukemia (1995) 9:480-500.
Bocchia, et al., Blood (May 15, 1995) 85:2680-2684.

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