Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-12-27
1996-09-24
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3144
Patent
active
055591159
ABSTRACT:
A compound isolated from Ervatamia microphylla has been found to be effective in inducing a change in cell morphology and growth habits of cultured transformant cell lines, and in reducing the tumor size in a living mammal. The compound is capable of inhibiting the function of oncogenes such as ras and src by inhibiting the function of the oncogene products. The compound is found to be represented by formula (I): ##STR1## Use of the compound as an oncogene function inhibitor, in a treatment of cancer, and in inducing changes in cell morphology and growth habits in transformant cell line are contemplated.
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Koyano Takashi
Takahashi Hiroaki
Umezawa Kazuo
Yamamoto Takashi
Goldberg Jerome D.
Terumo Kabushiki Kaisha
Umezawa Kazuo
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