Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1991-11-04
1993-09-07
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
53038825, 5303888, 53038885, 5303897, C07K 1514, C07K 1528
Patent
active
052430294
ABSTRACT:
Antibody defining structure present in fibronectins from tumors and fetal tissues but absent in fibronectins from normal adult tissues and plasma; useful for diagnosing and treating human cancers.
REFERENCES:
patent: 4894326 (1990-01-01), Matsuura et al.
Ali, I. U. and T. Hunter, Structural comparison of fibronectins from normal and transformed cells, J. Biol. Chem. 256(14):7671-7677, 1981.
Wagner, D. D. et al., Similarities and differences between the fibronectins of normal and transformed hamster cells, J. Biol. Chem. 256(22):11708-11715, 1981.
Sekiguchi, K., and S-i. Hakomori, Domain structure of human plasma fibronectin: differences and similarities between human and hamster fibronectins, J. Biol. Chem. 258(6):3967-3973, 1983.
Hayashi, M., and K. M., Yamada, Differences in domain structures between plasma and cellular fibronectins, J. Biol. Chem. 256(21):11292-11300, 1981.
Atherton, B. T., and R. O. Hynes, A difference beween plasma and cellular fibronectins located with monoclonal antibodies, Cell 25:133-141, 1981.
Ruoslahti, E., et al., Fibronectin from human germ-cell tumors resembles amniotic fluid fibronectin, Int. J. Cancer 27:763-767, 1981.
Zhu, B. C-R., et al., Human placental (fetal) fibronectin: increased glycosylation and higher protease resistance than plama fibronectin, J. Biol. Chem., 259(6):3962-3970, 1984.
Cossu, G., and L. Warren, Lactosaminoglycans and heparan sulfate are covalently bound to fibronectins synthesized by mouse stem teratocarcinoma cells, J. Biol. Chem. 258(9):5603-5607, 1983.
Murayama, K., et al., The carbohydrate structure of human fibronectins: a comparison between normal embryonic lung fibroblasts WI-38 and the SV40 virus transformed cell line VA13, Glycoconjugate J. 1:155-169, 1984.
Teng, M-H., and D. B. Rifkin, Fibronectin from chicken embryo fibroblasts contains covalently bound phosphate, J. Cell Biol. 80:784-791, 1979.
Liu, M-C., and F. Lipmann, Isolation of tyrosine-O-sulfate by pronase hydrolysis from fibronectin secreted by Fujinami sarcoma virus-infected rat fibroblasts, Proc. Natl. Acad. Sci. USA 82:34-37, Jan. 1985.
Sekiguchi, K., et al., Differences in domain structure between pericellular matrix and plasma fibronectins as revealed by domain-specific antibodies combined with limited proteolysis and S-cyanylation: a preliminary note, Biochem. Biophys. Res. Comm. 116(2):534-540, 1983.
Sekiguchi, K., et al., Differences in domain structure between human fibronectins isolated from plasma and from culture supernatants of normal and transformed fibroblasts: studies with domain-specific antibodies, J. Biol. Chem. 260(8):5105-5114, 25 Apr. 1985.
Zardi, L., et al., Somatic cell hybrids producing antibodies specific to human fibronectin, Int. J. Cancer 25:325-329, 1980.
Nakabayashi, H., et al., Growth of human hepatoma cell lines with differentiated functions in chemically defined medium, Cancer Res. 42:3858-3863, 1982.
Doi, I., Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma, Gann 67:1-10, 1976.
Matsuura, H., and S-i, Hakomori, The oncofetal domain of fibronectin defined by monoclonal antibody FDC-6: its presence in fibronectins from fetal and tumor tissues and its absence in those from normal adult tissues and plasma, Proc. Natl. Acad. Sci. USA 82:6517-6521, Oct. 1985.
Hakomori, S-i., and R. Kannagi, Glycosphingolipids as tumor-associated and differentiation markers, JNCI 71(2):231-251, 1983.
Kuusela, P., et al., Reactivity of hybridoma antibodies with amniotic and plasma fibronectin, Scand. J. Immunol. 12:331-337, 1980.
Matsuura, H., et al., The oncofetal structure of human fibronectin defined by monoclonal antibody FDC-6: unique structural requirement for the antigenic specificity provided by a glycosylhexapeptide, J. Biol. Chem. 263(7):3314-3322, Mar. 1988.
Atherton et al., "A Difference Between Plasma and Cellular Fibronectins located with Monoclonal Antibodies", Cell 25:133-141, Jul. 1981.
Hakomori Sen-itiroh
Matsuura Hidemitsu
Budens Robert D.
Fred Hutchinson Cancer Research Center
Lacey David L.
LandOfFree
Oncofetal structure of fibronectin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oncofetal structure of fibronectin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oncofetal structure of fibronectin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-488682