Oncofetal gene, gene product and uses therefor

Details Oncofetal gene, gene product and uses therefor Oncofetal gene, gene product and uses therefor

1990-10-01

1994-08-30

Lacey, David L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 693, 4353201, 4351723, 43525233, 530350, 536 231, 536 2431, C12N 1500, A61K 3900, C12P 2106, C07K 1500

Patent

active

053427610

ABSTRACT:
The present invention provides a novel cDNA sequence (Pem), a gene product protein (Seq. id No. 1), and uses for this novel cDNA Sequence and the Pem gene product. The DNA sequence and recombinant DNA molecules of this invention are characterized in that each codes for a novel protein having the following characteristics: (1) is expressed by T lymphoma cells, (2) is not expressed in normal thymus, activated spleen cells, gut associated lymphoid tissue, or bone marrow, and is not detectable in adult brain, liver, large intestine or ovary, (3) is expressed in immortalized or cancerous cell lines, and (4) is expressed in embryonic development.

REFERENCES:
Hedrick et al Nature 308: 149-153 (1984).
Hays et al, Int. J. of Cancer 38, 597-601 (1986).
McMichael et al Leukocyte typing III, pub. Oxford Univ. Press (1987) pp. 31-62 vol. 5.1.
Wilkinson et al, Dev. Biol. 141: 451-455 (1990).

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