On-resin peptide cyclization

Details On-resin peptide cyclization On-resin peptide cyclization

2011-08-09

2011-08-09

Bradley, Christina (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

C530S334000

Reexamination Certificate

active

07994280

ABSTRACT:
A novel compound of formula I is devised.

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Atherton et al. “Peptide Synthesis. Part 7. Solid-phase Synthesis of Conotoxin G1.” J. Chem. Soc. Perkin Trans., 1985, 1, 2065-2073.
Sieber “A new acid-labile anchor group for the solid-phase synthesis of C-terminal peptide amides by the Fmoc method.” Tetrahedron Lett., 1987, 28, 2107-2110.
Eritja et al. “On the use of s-t-butylsulphenyl group for protection of cysteine in solid-phase peptide synthesis using fmoc-amino acids,” Tetrahedron, 1987, 43, 2675-2680.
International Search Report for PCT/EP2005/011182 mailed Apr. 21, 2006.
Annis et al, “Disulfide Bond Formation in Peptides”, Methods in Enzymology, vol. 289, pp. 198-221 (1997).

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