Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2006-05-26
2009-02-03
Berman, Jack I (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S281000, C250S282000, C424S421000, C424S558000, C436S178000, C436S518000, C436S525000, C436S161000, C436S169000, C436S175000, C977S891000, C977S892000, C977S881000, C530S412000, C530S419000, C530S413000, C435S004000, C435S005000, C435S006120, C435S012000, C435S007100, C435S007200, C435S007230, C435S068100, C435S272000, C435S091500, C435S320100, C435S269000, C506S005000, C506S009000, C506S012000
Reexamination Certificate
active
07485855
ABSTRACT:
A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least one group of biological molecules with a surface of the support binding the molecules at a surface tension angle to the liquid of less than 180 degrees. The system includes an evaporator configured to evaporate liquid from the support, a solvent applicator configured to apply a solvent for dissolution of the contaminants in the sample, and a solvent removal device configured to remove applied solvent from the sample and thereby at least partially remove the contaminants.
REFERENCES:
patent: 6555813 (2003-04-01), Beecher et al.
patent: 2007/0275478 (2007-11-01), Taranenko et al.
patent: 2008/0193772 (2008-08-01), Agroskin et al.
James H. Strauss, Jr. et al., “Purification and Properties of Bacteriophage MS2 and of its Ribonucleic Acid”, J. Mol. Biol., 7, 1963, pp. 43-54.
Doris E. Terry, et al., “Optimized Sample-Processing Time and Peptide Recovery for the Mass Spectrometric Analysis of Protein Digests”, J. Am. Soc. Mass Spectrom., 15, 2004, pp. 784-794.
Hanjo Lim, et al., “Identification of 2D-Gel Proteins: A Comparison of MALDI/TOF Peptide Mass Mapping to μLC-ESI Tandem Mass Spectrometry”, J. Am. Soc. Mass Spectrom., 14, 2003, pp. 957-970.
Jacob M. Hooker, et al., “Interior Surface Modification of Bacteriophage MS2”, J. Am. Chem. Soc., vol. 126, No. 12, 2004, pp. 3718-3719.
Bryan M. Ham, et al., “MALDI-TOF MS of Phosphorylated Lipids in Biological Fluids Using Immobilized Metal Affinity Chromatography and a Solid Ionic Crystal Matrix”, Analytical Chemistry, vol. 77, No. 14, Jul. 15, 2005, pp. 4439-4447.
Ronald C. Beavis, et al., “Rapid, Sensitive Analysis of Protein Mixtures by Mass Spectrometry”, Proc. Natl. Acad. Sci. USA 87, vol. 87, Sep. 1990, pp. 6873-6877.
Maria Esteban Warren, et al., “On-Probe Solid-Phase Extraction/MALDI-MS Using Ion-Pairing Interactions for the Cleanup of Peptides and Proteins”, Analytical Chemistry, vol. 70, No. 18, Sep. 15, 1998, pp. 3757-3761.
Adam H. Brockman, et al., “Optimization of a Hydrophobic Solid-phase Extraction Interface for Matrix-Assisted Laser Desorption/Ionization”, Journal of Mass Spectrometry, 33, 1998, pp. 1141-1147.
Adam H. Brockman, et al., “Desalting Approach for MALDI-MS Using On-Probe Hydrophobic Self-Assembled Monolayers”, Analytical Chemistry, vol. 69, No. 22, Nov. 15, 1997, pp. 4716-4720.
Michael Karas, et al., “Laser Desorption Ionization of Proteins with Molecular Masses Exceeding 10 000 Daltons”, Analytical Chemistry, vol. 60, No. 20, Oct. 15, 1988, pp. 2299-2301.
Doroshenko Vladimir M.
Sundaram Appavu K.
Taranenko Nelli I.
Berman Jack I
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Sahu Meenakshi S
Science and Engineering Services, Inc.
LandOfFree
On-probe sample cleanup system and method for MALDI analysis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with On-probe sample cleanup system and method for MALDI analysis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and On-probe sample cleanup system and method for MALDI analysis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4055287