Liquid purification or separation – Processes – Chromatography
Patent
1990-10-09
1992-08-18
Therkorn, Ernest G.
Liquid purification or separation
Processes
Chromatography
2101982, 55386, B01D 1508
Patent
active
051396815
ABSTRACT:
An on-line multidimensional chromatographic system and method which couples a liquid chromatograph to a supercritical fluid chromatograph. The system includes an inlet column for depositing a fraction of interest eluting from the liquid chromatograph, an interface interposed between the inlet column and the supercritical fluid chromatograph for receiving and trapping an analyte from the deposited fraction on an impactor surface, and a valve arrangement for controlling fluid flow throughout the system. After the fraction of interest has been deposited in the inlet column, the liquid chromatograph solvent is removed from the inlet column, and then the deposited fraction is extracted from the inlet column in a supercritical fluid stream. The supercritical fluid stream is directed into the interface, where the analyte is trapped while the supercritical fluid is decompressed and vented. A subsequent supercritical fluid stream is then used to introduce the trapped analyte directly into the analytical column of the supercritical fluid chromatograph.
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Campbell Robert M.
Cortes Hernan J.
Himes R. Paul
Pfeiffer Curtis D.
The Dow Chemical Company
Therkorn Ernest G.
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