Radiant energy – Ionic separation or analysis – With sample supply means
Patent
1988-05-16
1989-07-25
Howell, Janice A.
Radiant energy
Ionic separation or analysis
With sample supply means
250281, 250423R, D01D 5944
Patent
active
048517003
ABSTRACT:
An improved liquid chromatography/mass spectrometer apparatus is disclosed of the type wherein the liquid eluent from a chromatograph column is injected as a heated spray into an ionization chamber located between the chromatograph and the mass spectrometer to form ionized adducts containing solvent and the molecule to be analyzed which are then passed into the mass spectrometer through an exit port in the sidewall of the ionization chamber. The improvement comprises an acceleration electrode located in the sidewall of the ionization chamber at a position opposite the exit port into the mass spectrometer, an electron emission source located between the acceleration electrode and the point of injection of the heated spray into the chamber, and means for providing a positive voltage on the acceleration electrode with respect to the electron emission source in the ionization chamber. The acceleration electrode is maintained at a voltage sufficiently high to permit a stream of electrons flowing from the electron emission source to the acceleration electrode to bombard the heated spray to form hydronium ions, and fragment at least a portion of the molecules being analyzed into two or more lower molecular weight constituents or molecular ions to thereby aid in identification of the molecule.
REFERENCES:
patent: 3997298 (1976-12-01), McLafferty et al.
patent: 4546253 (1985-10-01), Tsuchiya et al.
patent: 4647772 (1987-03-01), Lewis et al.
patent: 4667100 (1987-05-01), Lagna
Vestal, M. L., "Studies of Ionization Mechanisms Involved in Thermospray LC-MS", International Journal of Mass Spectrometry and Ion Physics, 46 (1983), pp. 193-196.
Aronoff Michael
Howell Janice A.
Sabath Robert P.
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