Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and

Details Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and

1984-05-30

1986-12-30

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514331, 514210, 514412, 514427, 546234, 548515, 548560, 548565, 548578, 548950, A61K 3140, A61K 31445, C07D20706, C07D20720

Patent

active

046329358

ABSTRACT:
OMEGA-(Hydroxy, ether and ester) alkyl-2-Amino-Cycloalkenyl and -cycloalkyl amide compounds of the formula: ##STR1## where the wavy line bonds, m, n, p, A, R, R.sub.1, R.sub.2, X, Y and Z are as defined in the specification, e.g., 3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-3-(3-acetyloxypropyl)cyclohexe nyl]benzamide, and pharmacologically acceptable salts thereof, are useful as analgesic drug compounds having low physical dependence liability, compared to morphine and methadone. Pharmaceutical compositions and methods for using these compounds and compositions as analgesics are disclosed. Processes for preparing this class of compounds are also disclosed.

REFERENCES:
patent: 4065573 (1977-12-01), Lednicer
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4145435 (1979-03-01), Szmuszkovicz
patent: 4212878 (1980-07-01), Lednicer et al.
patent: 4359476 (1982-11-01), Kaplan et al.
patent: 4360531 (1982-11-01), McMillan et al.
patent: 4438130 (1984-03-01), Kaplan
patent: 4460600 (1984-07-01), Kaplan et al.
patent: 4466977 (1984-08-01), McMillan et al.

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