Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1979-02-22
1980-11-04
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424285, 536 46, 536103, 542426, 542429, 26034622, 26034673, A61K 3170, A61K 3158, C07D307935
Patent
active
042320097
ABSTRACT:
Prostaglandin I.sub.2 analogues of the formula: ##STR1## [wherein Y represents ethylene or trans-vinylene, R.sup.1 represents hydrogen, alkyl of 1 to 12 carbon atoms, aralkyl of 7 to 12 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by at least one alkyl group containing from 1 to 4 carbon atoms, phenyl unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group, alkyl group containing from 1 to 4 carbon atoms or phenyl group, a --C.sub.m H.sub.2m COOR.sup.4 group (wherein m is an integer from 1 to 12 and R.sup.4 represents alkyl of 1 to 4 carbon atoms), a C.sub.n H.sub.2n OR.sup.5 group (wherein n is an integer from 2 to 12 and R.sup.5 represents hydrogen or alkyl of 1 to 4 carbon atoms), or a ##STR2## (wherein n is as hereinbefore defined and R.sup.6 and R.sup.7 each represent alkyl of 1 to 4 carbon atoms), R.sup.2 represents hydrogen, methyl or ethyl, X represents a --C.sub.p H.sub.2p --group (wherein p is an integer from 2 to 8) or a ##STR3## (wherein R.sup.8 represents a single bond, or alkylene of 1 to 4 carbon atoms, R.sup.9 represents a single bond or alkylene of 1 to 8 carbon atoms, and q is an integer from 3 to 6), R.sup.3 represents chlorine or fluorine, the wavy line attached to the carbon atoms in positions 11 and 15 represents .alpha.- or .beta.-configuration or mixtures thereof, and the double bond between C.sub.5 -C.sub.6 is Z] and cyclodextrin clathrates thereof and, when appropriate non-toxic salts, including acid addition salts, thereof, are new compounds possessing prostaglandin-like activity.
REFERENCES:
Chem. and Engineering News, Dec. 1976, p. 17.
Arai Yoshinobu
Hashimoto Shinsuke
Hayashi Masaki
Ohuchida Shuichi
Dentz Bernard
Jiles Henry R.
Ono Pharmaceutical Co. Ltd.
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