Omega conopeptide compositions

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

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530300, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

055874541

ABSTRACT:
Disclosed are novel omega conotoxin peptides effective in producing analgesia.

REFERENCES:
Basilico, L., et al., "Influence of .omega.-conotoxin on morphine analgesia and withdrawal syndrome in rats," European Journal of Pharmacology 218(1):75-81 (1992).
Basilico, L., et al., "Interaction of Opiates with .omega.-Conotoxin in Guinea Pig Ileum In Vitro," Pharmacological Research 21(1):65 (1989).
Benedek, G., and M. Sziksza, "Potentiation of thermoregulatory and anagesic effects of morphine by calcium antagonists," Pharmacological Research Communications 16(10):1009 (1984).
Ben-Sreti, M. M., et al., "Effects of elevated calcium and calcium antagonists on 6,7-benzomorphan-induced analgesia," European Journal of Pharmacology 90:385-391 (1983).
Carta, F., et al., "Effect of Nifedipine on Morphine-Induced Analgesia," Chemical Abstracts 114(19):abstract No. 178244t.
Contreras, E., et al., "Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance," European Journal of Pharmacology 148:463-466 (1988).
Del Pozo, E., et al., "Analgesic effects of several calcium channel blockers in mice," European Journal of Pharmacology 137:155-160 (1987).
Feldman, D. H., et al., "Omega Conus geographus toxin: a peptide that blocks calcium channels," FEBS Letters 214(2):295-300 (1987).
Hoffmeister, F., and D. Tettenborn, "Calcium agonists and antagonists of the dihydropyridine type: Antinociceptive effects, interference with opiate-.mu.-receptor agonists and neuropharmacological actions in rodents," Psychopharmacology 90:299-307 (1986).
Kavaliers, M., "Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity," Brain Research 408:403-407 (1987).
Konno, F., and I. Takayanagi, "Relationship between synaptosomal calcium uptake and antinociceptive action of morphine," Japan. J. Pharmacol. 33:619-626 (1983).
Lux, F., et al., "Interaction of Morphine with Intrathecally Administered Calcium and Calcium Antagonists: Evidence for Supraspinal Endogenous Opioid Mediation of Intrathecal Calcium-Induced Antinociception in Mice," J. Pharmacol. Exp. Therapeutics 246:500 (1988).
Mackie, K., and B. Hille, "Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells," Proc. Natl. Acad. Sci. USA 89:3825-3829 (1992).
Antkiewicz-Michaluk et al., "Role of calcium channels in effects of antidepressant drugs in responsiveness to pain," Chemical Abstracts 115(21):abstract No. 223387a.
Ocana, M., and J. M. Baeyens, "Analgesic effects of centrally administered aminoglycoside antibiotics in mice," Neuroscience Letters 126:67-70 (1991).
Olivera, B. M., et al., "Neuronal Calcium Channel Antagonists. Discrimination between Calcium Channel Subtypes Using .omega.-Conotoxin from Conus Magus venom," Biochemistry 26:2086-2090 (1987).
Prado, W. A., et al., "Antinociception induced by intraperitoneal injection of gentamicin in rats and mice," Pain 41:365-371 (1990).
Welch, S. P., and W. L. Dewey, "A Characterization of the Antinociception Produced by Intracerebroventricular Injection of 8-(N,N-Diethylamino)Octyl-3,4,5,-Trimethoxybenzoate in Mice," J. Pharmacol. Exp. Therapeutics 239:320 (1986).
Woodward, J. J., et al., "Differential sensitivity of synaptosomal calcium entry and endogenous dopamine release to .omega.-conotoxin," Brain Research 475:141-145 (1988).
Knaus, H-G., et al., "Neurotoxic aminoglycoside antibiotics are potent inhibitors [.sup.125 I]-Omega-Conotoxin GVIA binding to guinea-pig cerebral cortex membranes," Naunyn-Schmiedeberg's Arch Pharmacol 336: 583-586 (1987).
Wagner, J. A., et al., "Aminoglycoside effects on voltage-sensitive calcium channels and neurotoxicity," New England J. Medicine 317(26): 1669 (1987).

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