.omega.-Aryl-13,14-didehydro-PGF compounds

Details .omega.-Aryl-13,14-didehydro-PGF compounds .omega.-Aryl-13,14-didehydro-PGF compounds

1978-04-28

1981-06-30

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 61, 560 62, 562470, 562465, 260410, 2604105, 2604106, 260413, C07C17700

Patent

active

042764297

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
Fried et al., Proc. Nat. Acad. Science 70, 1579 (1973).

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