.omega.-Aryl-13,14-didehydro-PGE compounds

Details .omega.-Aryl-13,14-didehydro-PGE compounds .omega.-Aryl-13,14-didehydro-PGE compounds

1977-03-07

1981-02-03

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562463, 260410, 2604105, 260413, C07C17700

Patent

active

042490162

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
Fried et al., Proc. Nat. Acad. Sci. 70, 1579 (1973).

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