.omega.-Aryl-13,14-didehydro-interphenylene-PGF compounds

Details .omega.-Aryl-13,14-didehydro-interphenylene-PGF compounds .omega.-Aryl-13,14-didehydro-interphenylene-PGF compounds

1978-04-28

1979-05-22

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 53, 562465, C07C11700

Patent

active

041560892

ABSTRACT:
This invention comprises certain analogs of the prostagladins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3944595 (1976-03-01), Nelson
patent: 3980694 (1976-09-01), Bundy
Derwent Abstract 11148Y/07, BE 845-179, 14-02-77.
Derwent Abstract 09167X/05, US 3933-896, 20-01-76.

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